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Overview of Lesch-Nyhan Syndrome and Its Challenges Lesch-Nyhan syndrome is a rare genetic disorder primarily affecting males, characterized by a profound neurological and behavioral phenotype, along with a tendency towards self-mutilation and uric acid overproduction leading to gout-like symptoms. This condition is a consequence of a deficiency in the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT), crucial for […]